Infertility Panel

Helping you find answers to Infertility.

Connect with our experts

To Book a test

call : +91 75691 32891

What is an Infertility Panel?

Infertility affects millions of couples worldwide. While often perceived as a single condition, infertility can stem from a wide array of causes, with genetic factors playing a role in up to 50% of cases. Our genetic infertility panels move beyond standard hormone profiling and imaging. We evaluate DNA to understand the root cause of reproductive challenges and guide your path to parenthood.

Female Infertility Panel

  • From a genetic standpoint, female infertility often involves abnormalities that disrupt the process of meiosis (egg maturation), hormonal signaling, or structural development of reproductive organs.
  • Chromosomal Aneuploidies: Conditions like Turner Syndrome (45,X) or mosaic variants often lead to premature ovarian failure.
  • Single Gene Defects: Mutations in genes involved in folliculogenesis, hormone receptors (e.g., FSH receptor), or ovarian function.
  • Premutation Expansions: Specifically in the FMR1 gene, which is directly linked to Fragile X syndrome and ovarian dysfunction.

Male Infertility Panel

  • Genetically, male infertility is most frequently a story of missing genes or silent deletions. It often manifests as azoospermia (no sperm) or severe oligospermia (low sperm count).
  • Sex Chromosome Aneuploidy: Klinefelter Syndrome (47,XXY) is a leading cause.
  • Y Chromosome Microdeletions: Specific regions on the Y chromosome (AZF regions) contain genes critical for spermatogenesis. If these are deleted, sperm production halts.
  • CFTR Mutations: Beyond infertility, men with Congenital Bilateral Absence of the Vas Deferens (CBAVD) carry mutations in the CFTR gene.

Who should consider genetic infertility testing?

  • Individuals with: Unexplained elevated FSH, low AMH, primary/secondary amenorrhea, or family history of early menopause or Fragile X syndrome (females).
  • Confirmed non-obstructive azoospermia or severe oligospermia (<5 million/mL) (males).
  • Recurrent pregnancy loss (≥2 miscarriages) or failed IVF cycles (couples).
  • Family history of intellectual disabilities (Fragile X carrier risk).
  • High-risk ethnic background for specific genetic conditions.
  • Men considering surgical sperm retrieval.
  • Women considering elective egg freezing (oocyte cryopreservation).

Test Specification

Karyotype

Methodology: Cell culture & G-banding

Coverage:

  1. Resolution: 5–10 Mb. Identifies 47,XXY (Klinefelter), 46,XX male syndrome, and balanced translocations.
  2. Resolution: 5–10 Mb. Identifies Turner syndrome (45,X), mosaicism, translocations, and inversions.

Y Chromosome Microdeletion

Methodology: Multiplex PCR

Coverage:

  • Specifically targets AZFa, AZFb, and AZFc regions.
  • AZFc deletion: Most common; potential for residual sperm production.
  • AZFa/b: Poor prognosis for sperm retrieval.

WES

  • Targets genes linked to spermatogenic failure, sperm morphology defects, hormonal axis disorders, and syndromic infertility.
  • 98% exonic coverage with integrated CNV analysis, including genes associated with ovarian dysgenesis, hypogonadotropic hypogonadism, and syndromic infertility.

Fragile X

Methodology: TP-PCR

Coverage:

  • Detects CGG repeat expansions in the FMR1 gene.
  • Normal: ~5–44 repeats
  • Intermediate: 45–54 repeats
  • Premutation: 55–200 repeats
  • Full Mutation: >200 repeats

Connect with our expert

Why choose OneDNA

Comprehensive Coverage

Comprehensive testing across both molecular and cytogenetic platforms

Accredited Laboratories

NABL & CAP accredited lab

Support & Care

End-to-end support including genetic counselling and report guidance.

Early & Accurate

High accuracy with advanced technologies and stringent quality controls

Download our brochure

Download our brochure to learn more about Infertility Panel

Download now

Frequently Asked Questions

It helps identify underlying genetic causes that may impact treatment success and guides personalized reproductive strategies.

Yes, certain findings (e.g., Y microdeletions or low ovarian reserve genes) can indicate prognosis and chances of success.

It detects deletions in AZF regions critical for sperm production and helps assess sperm retrieval potential.

WES identifies rare or novel gene mutations affecting reproductive function that are missed by conventional tests.

Because FMR1 permutations are strongly associated with premature ovarian insufficiency and reproductive challenges.

Some Blogs from us

Sudden Cardiac Arrest: A Growing Health Crisis in India

Sudden cardiac arrest (SCA) is one of the most devastating cardiovascular emergencies. SCA happens when the electrical system of the heart malfunctions, resulting in deadly arrhythmias, as opposed to a heart attack, which is brought on by limited blood supply to the heart muscle.

See more

Genetic Keys to Cracking Testicular Cancer

Testicular cancer is a highly treatable form of cancer that develops in the testicles, which are the male reproductive glands responsible for producing sperm and testosterone.

See more

Our Companies

Screens for 90+ conditions

Get in touch

Have questions or need assistance? Get in touch with our team—we’re here to help.

Fill out the form below to get instant access to the product brochure.