Hematological Genetic Testing

Identify actionable mutations to guide targeted therapy.

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What is Hematological Genetic Testing?

In hematological malignancies, genetic testing is performed on blood, bone marrow aspirates, or lymph node samples. It focuses on identifying chromosomal translocations, gene fusions, somatic mutations, and clonal abnormalities that define specific disease subtypes.

Which Hematological panels do we offer?

  • Acute Leukemia Reflex Panel
  • ALL Multiplex PCR Panel
  • AML Multiplex Advanced
  • MPN Reflex Panel
  • CLL Panel
  • PCR BCR-ABL1 Qualitative Assay
  • PCR PML-RARA t(15;17) Qualitative Assay
  • Myeloid gene panel

Who can consider Hematological malignancies testing?

  • Suspected cases of leukemia, lymphoma, or multiple myeloma
  • Unexplained cytopenias or persistent leukocytosis
  • Abnormal peripheral smear or bone marrow findings
  • To guide targeted therapy and treatment decisions
  • Disease progression or relapse evaluation (resistance mutation detection)
  • Monitoring measurable residual disease (MRD)

Key Parameters covered under the panels

Acute Leukemia Reflex Panel

Structural Chromosomal Aberrations +Molecular Markers

ALL Multiplex PCR Panel

(t(9;22) t(12;21) t(1;19) t(4;11)

AML Multiplex Advanced

(BCR-ABL, PML-RARA, AML- ETO, Inv 16, NPM1, FLT3, CEBP

MPN Reflex Panel

BCR-ABL1 QL JAK2V617F JAK2 exon 12 CALR MPL

CLL Pane

23 genes

PCR BCR ABL1 Qualitative Assay

BCR ABL1 (p190, p210 & p230)

PCR PML/ RARA t(15;17) Qualitative Assay

PML/RARA t(15;17)

Myeloid gene panel

90 genes

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Why choose OneDNA

Comprehensive Coverage

Comprehensive testing across both molecular and cytogenetic platforms

Accredited Laboratories

NABL & CAP accredited lab

Support & Care

End-to-end support including genetic counselling and report guidance.

Early & Accurate

High accuracy with advanced technologies and stringent quality controls

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Frequently Asked Questions

It plays a big role in treatment. Certain genetic findings help doctors choose targeted therapies that are more effective and sometimes less toxic than standard treatments.

Not at all. Genetic testing is often useful during and after treatment as well, especially to monitor response and detect any residual disease early.

Not necessarily. Mutations help doctors understand the disease better, they’re used to guide treatment, not just indicate severity.

Yes. It can detect very small amounts of disease, helping doctors understand how well the treatment is working.

It doesn’t change the disease itself, but it helps doctors choose more precise and effective treatments, which can improve outcomes.

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