Solid Tumor Genetic Testing

Clarity that helps choose the right therapy.

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What Solid Tumor Genetic Testing?

Genetic testing in solid tumors involves analyzing tumor tissue obtained through biopsy or surgical resection. The DNA extracted from the tumor is examined for somatic mutations, gene amplifications, chromosomal rearrangements, and copy number variations. In India, 1 in 9 is likely to develop cancer in their lifetime.

Which Solid Tumor panels do we offer?

  • 1. Organ-specific cancer panels: Lung cancer panel, BRCA1 & BRCA2, endometrial cancer panel, colorectal cancer panel, GIST panel (KIT, PDGFR), and more.
  • 2. Microsatellite instability disorders: MLH1, MSH2, MSH6, PMS2.
  • 3. Tumor Mutation Burden (TMB)
  • 4. Homologous Recombination Repair (HRR) and Homologous Recombination Deficiency (HRD) panel.

Who can consider testing ?

  • 1. Patients diagnosed with solid tumors such as lung, colorectal, endometrial, or GIST cancers.
  • 2. Individuals being evaluated for targeted therapies (e.g.BRCA1/2, HRR/HRD, MSI status).
  • 3. Patients with advanced or metastatic cancers requiring precision treatment selection.
  • 4. Cases with treatment resistance or disease progression to identify new actionable mutations.
  • 5. Individuals with suspected microsatellite instability (MSI) related cancers.
  • 6. Patients where tumor mutation burden (TMB) assessment may guide immunotherapy decisions.

Key Actionable Genes

Breast & Ovary

BRCA1, BRCA2, AKT1, PTEN, TP53, ESR1, PIK3CA, MSI RAD51C, RAD51D, PALB2

Colorectal

KRAS, NRAS, HRAS, BRAF, Her2, MSI

Lung

12 gene : - EGFR, BRAF, KRAS, HER2, ROS1, ALK, PIK3CA, RET , MET, NRAS, FGFR2 and NTRK 1,2

Endometrial

POLE, TP53, MSI

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Why choose OneDNA

Comprehensive Coverage

Comprehensive testing across both molecular and cytogenetic platforms

Accredited Laboratories

NABL & CAP accredited lab

Support & Care

End-to-end support including genetic counselling and report guidance.

Early & Accurate

High accuracy with advanced technologies and stringent quality controls

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Frequently Asked Questions

Because not all tumors behave the same, even if they’re from the same organ. This test helps understand the exact genetic makeup of your tumor, which can directly impact treatment.

They’re looking for specific genetic changes like mutations, amplifications, or markers (like MSI or TMB) that can guide treatment decisions.

That can happen. It doesn’t mean the test failed, it just means there may not be a currently actionable target, and your doctor will guide the next steps.

It’s most commonly used in advanced or metastatic cancers, but it’s increasingly being used earlier to personalize treatment from the start.

Instead of treating based only on cancer type (like lung or colon), this approach treats based on the specific genetic drivers of your tumor.

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