Gastrointestinal Genetics

Clarity for hereditary gastrointestinal disease risk

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What is Gastrointestinal Genetics?

Gastrointestinal disorders are a growing concern in India, with colorectal cancer alone accounting for over 60,000 new cases annually. OneDNA’s gastrointestinal genetic testing helps identify underlying genetic causes, enabling accurate diagnosis, improved risk assessment and personalised strategies for treatment and long term management.

Which gastrointestinal conditions can be diagnosed?

  • Hereditary colorectal cancer syndromes (e.g., Lynch syndrome, FAP)
  • Inflammatory bowel disease with genetic predisposition
  • Hereditary pancreatitis
  • Celiac disease (genetic susceptibility)
  • Liver disorders (e.g., Wilson disease, hemochromatosis)
  • Polyposis syndromes and other GI tract cancers

Who can consider testing ?

  • Individuals with early onset gastrointestinal cancers
  • Patients with a family history of GI cancers or hereditary syndromes
  • Individuals with recurrent or unexplained GI symptoms
  • Patients with polyps or multiple GI lesions
  • Individuals with suspected hereditary liver or pancreatic disorders
  • Family members of patients with known genetic GI conditions

Test specifications

Methodology

WES (Next Generation Sequencing)

Specificity & Sensitivity

99-100%

Coverage

80-100x Depth

Sample type

Blood in EDTA

TAT

4 weeks

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Why choose OneDNA

Comprehensive Coverage

Comprehensive testing across both molecular and cytogenetic platforms

Accredited Laboratories

NABL & CAP accredited lab

Support & Care

End-to-end support including genetic counselling and report guidance.

Early & Accurate

High accuracy with advanced technologies and stringent quality controls

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Frequently Asked Questions

Many gastrointestinal conditions are influenced by genetics and may run in families. Genetic testing helps detect risks early, allowing better prevention, monitoring, and treatment planning.

It does not predict cancer with certainty, but it can identify genetic risks that may increase the likelihood of developing certain GI cancers in the future.

No. It does not replace imaging or clinical tests. It helps guide whether those tests are needed earlier or more frequently.

No. It focuses on inherited genetic causes, not diet or infection-related digestive issues.

Usually no. Genetic results remain the same throughout life unless new clinical tests are advised.

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