Germline Testing

Identify inherited risks early, manage them better

Connect with our experts

To Book a test

call : +91 75691 32891

What is Germline Testing

Germline cancer testing is a genetic test that analyzes a group of cancer susceptibility genes to identify inherited mutations associated with increased cancer risk. These panels typically include high- and moderate-penetrance genes such as BRCA1, BRCA2, TP53, MLH1, MSH2, MSH6, PMS2, APC, and others, depending on the panel design. The test is used to diagnose hereditary cancer syndromes, guide personalized screening and risk-reduction strategies, inform treatment decisions (including targeted therapies), and enable cascade testing for at-risk family members.

Which Germline panels do we offer?

  • Hereditary Cancer Panel
  • BRCA1 & BRCA2 gene testing
  • Retinoblastoma gene testing
  • Homologous Recombination Repair (HRR) gene panel

Who can consider testing ?

  • Strong family history of cancers across generations
  • Patients with multiple primary cancers in the same or different organs
  • Individuals with early-onset cancers (e.g., breast, colorectal, ovarian at a young age)
  • Patients with cancers suggestive of hereditary syndromes
  • Individuals with abnormal tumor screening results

Key Actionable Genes

Connect with our expert

Why choose OneDNA

Guideline-Driven Testing

A high-quality laboratory follows internationally accepted standards such as the NCCN and ACMG guidelines to ensure gene selection, variant interpretation.

High Analytical Accuracy

A reliable laboratory combines advanced technologies like next-generation sequencing (NGS) with robust validation processes to deliver highly accurate results.

Comprehensive Oncology & Genetic Portfolio

A holistic patient care approach offering somatic and germline testing, advanced liquid biopsy for tumor profiling, pharmacogenomics, and preventive genomics. This integrated platform supports diagnosis, treatment selection, drug response, and long-term risk assessment for precise, personalized healthcare decisions.

Clinically actionable reports

Following ACMG guidelines, variants are classified as pathogenic, likely pathogenic, or VUS. Reports include therapy implications, prognostic insights, and risk assessment, presented in a concise, clinician-friendly format for quick, informed decision-making.

Get our brochure

Download our brochure to learn more about Germline Testing

Frequently Asked Questions

Some tests look at mutations only in the tumor. Germline testing checks if the risk is present in your entire body and family line, not just the cancer itself.

Because this test is about future risk, not current health. It helps you take preventive steps before any symptoms appear.

Yes. Family history helps, but it’s not always complete or accurate. Some genetic risks can be hidden or previously undiagnosed.

Potentially, yes. If a mutation is found, your close relatives may also carry it. This allows families to take preventive action together.

Awareness ahead of time. It gives you and your family the chance to act early instead of reacting later.

Some Blogs from us

Folate Receptor Autoantibodies in Autism Spectrum Disorder

Sudden Cardiac Arrest: A Growing Health Crisis in India

Sudden cardiac arrest (SCA) is one of the most devastating cardiovascular emergencies. SCA happens when the electrical system of the heart malfunctions, resulting in deadly arrhythmias, as opposed to a heart attack, which is brought on by limited blood supply to the heart muscle.

Genetic Keys to Cracking Testicular Cancer

Testicular cancer is a highly treatable form of cancer that develops in the testicles, which are the male reproductive glands responsible for producing sperm and testosterone.

Our Companies

Screens for 90+ conditions

Get in touch

Have questions or need assistance? Get in touch with our team—we’re here to help.

Fill out the form below to get instant access to the product brochure.